Atrodas pilsētas centrā, Atbrīvošanas alejā 98. Dievnamu sāka celt 1840. g. (iesvētīja 1846. g.) un tas uzskatāms par pilsētas vecāko sakrālo būvi. Nekvalitatīvu būvniecības materiālu izmantošana un cēlāju pieredzes trūkums bija iemesls, kādēļ 1854. g. to nācās pārbūvēt. Pie baznīcas atrodas 1867. g. būvēta Sv. A. Ņevska kapliča, kas veltīta cara Aleksandra II paglābšanās faktam vilciena katastrofā un stikla mauzolejs, kurā apbedīts baznīcas mecenāts ģenerālis Karaulovs (šobrīd tiek restaurēts). Dievnams ir atvērts arī apmeklētājiem.

The present wooden church on the hill was built in 1947 but today it has been restored. Currently, the deanery of Rezekne is located there. Every day you can see it from the outside. Until 1960, in Dukstigals there were two congregations: White Dukstigals (Šadurska) and Black Dukstigal (Slobodska). In White Dukstigals, the church was built in 1775. In 1960, during the time of the Soviet power, the church was violently demolished, despite the fact that it was an architectural monument and the oldest wooden church in Latgale-367years old! The "excuse" was the explanation that one congregation must not have two churches.

The Zasa Lutheran Church is in the northern part of the Zasa park, was built in 1750, and is a small Lutheran church. The organ, which was produced by the distinguished organ builder Andrejs Sūnākslis, was recently restored. The graves of German soldiers who fell during World War I are near the church.

The Rēzekne Old Believer Prayer House of St Nicholas is in the southern part of the city, at Siņicina Street 4. The house of worship was built in 1895 and rebuilt in 1906. Its tower has three silver and brass bells (restored), and one of them is thought to be the largest bell in Latvia (4,832 kg with a tongue that weighs 200 kg in and of itself). Alongside is a museum which features the cultural and religious environment of the Old Believers.

The St George Lutheran Church of Subate is on the north-eastern shore of Lesser Lake Subate. The church was built in the Byzantium style in 1685 and 1868 and was commissioned by the owner of the Prode Estate, H.F. Osten-Sacken. This is the only church in Latvia which is reminiscent of the typical appearance of Protestant churches in the late 17^th century. The small towers at the corners of the building are of interest. Inside you will find a richly ornamented ensemble of sculptures and wood carvings, including a 17^th-century altar, pulpit and pews, as well as artworks from the 17^th and 18^th century and a bell that was cast in 1682. Some of the interior design was the work of students at the Stelmuže wood carving school.

When you drive down the Nereta-Ilūkste road, the church, which was built in 1805 and restored in 1888, can be seen from a distance. The altar, pulpit and organ prospectus are all original. German soldiers who fell during World War I are buried outside of the church. Two plaques on the western wall of the building honour residents of the Laši Parish who died during the First World War, as well as those local residents who suffered Soviet repressions.

Atrodas Ganību ielā 120. Celta (iesvētīta 2001. g.) mūsdienu modernās arhitektūras formās un interesanta ar faktu, ka sākotnēji bijusi Vatikāna paviljons Pasaules izstādē “Expo 2000” Hannoverē. To pārbūvēja un uz Liepāju pārcēla par Vācijas katoļu saziedotajiem līdzekļiem. Ēkā darbojas katoļu draudzes centrs.

Atrodas Jasmuižas austrumdaļā. Dievnams celts 1815. g., bet pārbūvēts 1932. g.

Pühtittsa Convent at Kuremäe was established in 1891 and is the only operating Russian Orthodox nunnery in Estonia. Centuries ago there was a sacred grove on Kuremäe hill and a sacrificial spring at its foot, the spring is considered “holy“ for its curative powers. The convent compound is open to visitors; guided tours run by nuns can be booked to learn more about the daily life of convent residents.